Rotigotine transdermal system: a short review
نویسندگان
چکیده
Rotigotine (Neupro((R))) is a new non-ergolinic dopamine agonist transdermal patch that can be applied once daily. To date, it is approved for the treatment of early Parkinson's disease as monotherapy and has been shown to be effective in the treatment of advanced-stage Parkinson's disease and restless legs syndrome in several clinical trials. This review gives an overview of physical, chemical, and pharmaceutical characteristics, pharmacokinetics, biotransformation and elimination, drug interactions, and adverse events of rotigotine. Further, the rationale for the treatment of Parkinson's disease and restless legs syndrome with rotigotine is discussed.
منابع مشابه
Rotigotine Transdermal Patch for the Treatment of Restless Legs Syndrome
Rotigotine, a nonergot dopamine agonist, has been developed as a novel transdermal formulation. The rotigotine transdermal patch has received EMA and FDA marketing authorization for the treatment of adult patients with early or advanced Parkinson’s disease or with moderate-to-severe restless legs syndrome (RLS). This review comprises an overview of the pharmacokinetics, the pharmacodynamics and...
متن کاملAn Update on Pharmacological, Pharmacokinetic Properties and Drug–Drug Interactions of Rotigotine Transdermal System in Parkinson’s Disease and Restless Legs Syndrome
This narrative review reports on the pharmacological and pharmacokinetic properties of rotigotine, a non-ergolinic D₃/D₂/D₁ dopamine receptor agonist approved for the treatment of early- and advanced-stage Parkinson's disease (PD) and moderate to severe restless legs syndrome (RLS). Rotigotine is formulated as a transdermal patch providing continuous drug delivery over 24 h, with a plasma conce...
متن کاملRotigotine Transdermal Patch in Parkinson’s Disease: A Systematic Review and Meta-Analysis
BACKGROUND AND METHODS The efficacy and safety of rotigotine transdermal patch in Parkinson's disease (PD) were studied in some clinical trials. We performed a systematic review and meta-analysis of randomized controlled trials to evaluate the efficacy, tolerability, and safety of rotigotine transdermal patch versus placebo in PD. RESULTS Six randomized controlled trials (1789 patients) were ...
متن کاملAuthor's response to reviews Title: Transdermal rotigotine for the perioperative management of restless legs syndrome Authors:
1) Study's objective is "To assess rotigotine transdermal patch for the perioperative management of moderate to severe RLS". To assess what? Efficacy? Feasibility of use? The objective of this posthoc analysis was to assess the feasibility of use of rotigotine transdermal patch for the perioperative management of moderate to severe RLS. Efficacy data for the entire study population, including p...
متن کاملTransdermal rotigotine for the perioperative management of restless legs syndrome
BACKGROUND Immobilisation, blood loss, sleep deficiency, and (concomitant) medications during perioperative periods might lead to acute exacerbation of symptoms in patients with the restless legs syndrome (RLS). Continuous transdermal delivery of the dopamine agonist rotigotine provides stable plasma levels over 24 h and may provide RLS patients with a feasible treatment option for perioperativ...
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ورودعنوان ژورنال:
- Neuropsychiatric Disease and Treatment
دوره 2 شماره
صفحات -
تاریخ انتشار 2006